Endocrine Abstracts

Calcium is important for physiological functioning in many tissues and is essential in mucus secretion. Previously reported, Mucin secretion is regulated predominantly by cytosolic calcium-dependent pathways. Cytosolic of calcium are regulated by calcium channels such as TRPV6, NCX1, and PMCA1. A549 cell line was treated with 10−8 M dexamethasone (DEX) and 10−6 M RU486. Subsequently, the expression of TRPV6, NCX1, and PMCA1 in A549 cell line w...

Introduction: Dexamethasone inhibits mucin secretion considering the primary option for treating acute asthma exacerbation. However, the mechanism underlying dexamethasone-induced decreased in mucosecretion is unclear. Recent studies have reported that dexamethasone exerts an inhibitory effect on mucosecretion in the lung by modulating the expression of calcium-processing genes. However, the expression of the calcium-processing genes in trachea are not examined yet. Thus, the ...

NCKX3 (Sodium/potassium/calcium exchanger 3), a novel member of the family of K+-dependent Na+/Ca2+ exchangers, is an important component of intracellular Ca2+ homeostasis. Ca2+ homeostasis has been extensively studied in various cell systems. Dysregulation of Ca2+ homeostasis can induce the excitotoxic and neurodegeneration in central nervous system. NCKX3 gene is highly expressed in thalamic nuclei, in hippoca...

Cellular Ca2+ signals have been proposed to activate signal for hormone secretion. In pancreatic β cell which produce insulin, Ca2+ signals have been known contributing insulin secretion. Prior to conduct this study, we confirmed calbindin-D9k (CaBP-9k) which responsible for regulation of the distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, ...

Calcium is important for physiological functioning in many tissues and is essential in mucus secretion and muscle contraction. Intracellular concentrations of calcium are regulated by calcium-related proteins such as TRPV4, TRPV6, CaBP-9k, NCX1, and PMCA1. In this study, the relationship between secretion of pulmonary mucus and calcium regulation was investigated. To confirm the effect of steroid hormones, immature mice were injected with estrogen (E2) or progesterone (P4) and...